[Table of Contents]

Plasma and Fusion Research

Volume 5, S2117 (2010)

Regular Articles

Irradiation Experiments on a Mouse Using a Mild-Plasma Generator for Medical Applications
Hajime SAKAKITA and Yuzuru IKEHARA1)
Energy Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 2, 1-1-1 Umezono, Tsukuba 305-8568, Japan
Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 2, 1-1-1 Umezono, Tsukuba 305-8568, Japan
(Received 6 January 2010 / Accepted 18 March 2010 / Published 10 December 2010)


Plasma technologies using an argon plasma coagulator have been used in endoscopic therapy to induce blood coagulation and ablate residual tumors. However, present devices have a risk of perforating the stomach wall during endoscopic submucosal dissection. Therefore, to reduce this risk, irradiation is performed for a limited time, which leads to incomplete cessation of bleeding and recurrence of residual tumors. Therefore, a device with greater controllability and safety is strongly desired for clinical applications. In this study, we have evaluated the irradiation efficiency of an atmospheric-pressure plasma jet based on a dielectric barrier discharge to control bleeding. Bleeding from a mouse femoral artery was induced, and then plasma was irradiated onto the bleeding area. Prompt coagulation in the disrupted blood vessel was observed, and there was no histological evidence of either burns or tissue necrosis caused by the plasma jet. These results suggest that postoperative scarring and adhesion may be prevented using the proposed plasma generator because of the reduced tissue damage.


blood coagulation, dielectric barrier discharge, atmospheric-pressure plasma jet, histopathological observation, C57BL6 mouse, femoral artery, mouse brain

DOI: 10.1585/pfr.5.S2117


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This paper may be cited as follows:

Hajime SAKAKITA and Yuzuru IKEHARA, Plasma Fusion Res. 5, S2117 (2010).