Plasma and Fusion Research
Volume 5, S2117 (2010)
Regular Articles
- Energy Technology Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 2, 1-1-1 Umezono, Tsukuba 305-8568, Japan
- 1)
- Research Center for Medical Glycoscience, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba Central 2, 1-1-1 Umezono, Tsukuba 305-8568, Japan
Abstract
Plasma technologies using an argon plasma coagulator have been used in endoscopic therapy to induce blood coagulation and ablate residual tumors. However, present devices have a risk of perforating the stomach wall during endoscopic submucosal dissection. Therefore, to reduce this risk, irradiation is performed for a limited time, which leads to incomplete cessation of bleeding and recurrence of residual tumors. Therefore, a device with greater controllability and safety is strongly desired for clinical applications. In this study, we have evaluated the irradiation efficiency of an atmospheric-pressure plasma jet based on a dielectric barrier discharge to control bleeding. Bleeding from a mouse femoral artery was induced, and then plasma was irradiated onto the bleeding area. Prompt coagulation in the disrupted blood vessel was observed, and there was no histological evidence of either burns or tissue necrosis caused by the plasma jet. These results suggest that postoperative scarring and adhesion may be prevented using the proposed plasma generator because of the reduced tissue damage.
Keywords
blood coagulation, dielectric barrier discharge, atmospheric-pressure plasma jet, histopathological observation, C57BL6 mouse, femoral artery, mouse brain
Full Text
References
- [1] S. Kanazawa et al., J. Phys. D: Appl. Phys. 21, 838 (1988).
- [2] K. Tachibana et al., Plasma Phys Control. Fusion 47, A167 (2005).
- [3] H. Eto et al., Appl. Phys. Lett. 93, 221502 (2008).
- [4] E. Stoffels et al., Plasma Sources Sci. Technol. 15, S169 (2006).
- [5] H. Sakakita et al., Proc. 25th Symp. on Plasma Processing, 137 (2008).
- [6] H. Sakakita et al., Int. Cong. Plasma Phys. 2008, Fukuoka FH1, P1-117 (2008).
- [7] K. E. Grund et al., Endosope Surgery 2, 42 (1994).
- [8] G. Fridman et al., Plasma Process. Polym. 5, 503 (2008).
- [9] H. Sakakita et al., Japanese Patent, No. 2009-144262 (2009).
- [10] M. Teschke et al., Proc. 48th Annual Tech. Conf., Society of Vacuum Coasters 505/856-7188, 1 (2005).
- [11] M. Teschke et al., IEEE Trans. Plasma Sci. 33, 310 (2005).
- [12] K. Yambe et al., J. Plasma Fusion Res. Series 8, 1322 (2008).
- [13] Y. A. Gonzalvo et al., J. Vac. Sci. Technol. A24, 550 (2006).
This paper may be cited as follows:
Hajime SAKAKITA and Yuzuru IKEHARA, Plasma Fusion Res. 5, S2117 (2010).